Sekondi-Takoradi port is situated on the Gulf of Guinea (Atlantic Ocean) in southern Ghana. Both the Dutch and British built forts at Sekondi in the 17th century that were destroyed by the Ahanta. Fort Orange, rebuilt by the Dutch and bought by the British in 1872, still survives as a lighthouse. Sekondi flourished in the 1900s after construction of the railroad (1903) to the mineral and timber resources of the hinterland & the interior goldfields. A deepwater harbour was constructed at Takoradi in 1928.

Takoradi is Ghana's mail export port with around 500 vessel calls per year handling 65% of Ghana's exports. Main commodities are manganese, bauxite, timber and cocoa. Takoradi handles over 2.2 million tons of cargo per year.

Sekondi and Takoradi, a single municipality since 1946, became one city in 1963. Takoradi is well-planned, with two breakwaters enclosing 220 acres (90 hectares) of sea with quay berths (5 multi-purpose and 3 dedicated berths) and lee facilities for loading bauxite and discharging oil. The harbour is the terminus of several Ghana railways and is served by road and air. Sekondi-Takoradi also has light industrial, agricultural, and fishing enterprises.

Sekondi-Takoradi also has shipbuilding, railroad repair, and cigarette industries. The two parts of the city developed around Dutch and English forts built in the 17th century.
Takoradi port is gearing up for futher upgrades and increased private sector participation. The Port Authority has secured land close to the harbour to be leased to private investors for the development of fish processing and cold storage facilities. There are also plans to extend the clinker-bauxite jetty and the main breakwater. The old log pond will be reclaimed for use as a container handling area and there are also plans for the construction of new offices and a marine operation berth.